• Contains 2 scientifically proven performance enhancing ingredients in one compound; Creatine and Orotic Acid.
• Higher energy complex providing greater endurance and contractile force.
• Contains Patented CreaTate™ (Tricreatine Orotate )
• Boosts muscle phosphocreatine more effectively by providing creatine as well as Orotic Acid which increases muscle Uridine levels. Elevation of intramuscular Uridine levels increase muscle phosphocreatine and creatine levels 38% and 3%, respectively.
• The only form of creatine that can boost muscle carnosine concentrations.
• Great for sprinting.

This Creatine/Orotic Acid complex, also known as "The King of Creatines™", pushes the power to fight muscle fatigue to completely new levels. Not only do you get the scientifically proven power, endurance and recovery of creatine supplementation, but you also get the high energy, power, recovery and growth stimulating properties of Orotic Acid.

Orotine™ contains the patented CreaTate™ Tricreatine Orotate (creatine + orotic acid) complex; an exclusive Creatine and Orotic Acid infusion. A genuine revolutionary breakthrough, creatine has been scientifically proven effective in maintaining ATP levels and increasing recovery during and following high intensity exercise. It is also a proven cell-volumizer. Creatine functions similar in fashion to carnosine in that it helps with the maintenance of cellular pH. Maintaining proper cell pH enhances performance. More evidence suggests creatine can reduce muscle damage from endurance exercise making it a great supplement for endurance and power athletes alike.

Stacks well with Body Octane.

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225-0009 MAN Orotine Capsules 272 capsules Nutrition Facts Serving Size: 4 capsules Servings Per Container: 68 Amount Per Serving % Daily Value* Orotine(tm) (Creatine Orotate) 3,000  mg   *Percent Daily Values are based on a 2,000 calorie diet.   Recommended Use: Take 2 servings daily with or without food separated by at least 4 to 5 hours. Orotine(tm) can also be combined with Blueprint(tm), Bodyoctane(tm), Primale Male(tm) and other Man Sports(tm) Before beginning any program of weight loss, consult your health care practitioner. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you notice any errors in the information above, please let us know. If you have further questions about this product, please contact MAN at 1-866-320-5569 The nutrition facts listed above are supplied as a courtesy to our customers. The nutrition facts were current and accurate to the best of our knowledge at the time they were entered. Manufacturers often change formulas or ingredients without notifying us. We do our best to keep them as up to date as possible, however Netrition.com will not be held responsible for any differences between what is listed on our web site and what is listed on the product that you receive. If you need to be 100% certain of the ingredients currently being shipped, we recommend that you call or email our customer service department to check the shelf of current stock.

Orotic Acid (OA) is a precursor of pyrimidine and nucleic acids which are vital for optimal cell functioning and energy metabolism. OA enhances and maintains ATP pools in three ways:

1. The production of ribose moieties (R-1-P and R-5-P) for the salvage or de novo synthesis of purine nucleotides by a process know as "ribose transfer". Many of you may remember ribose (a sugar component of ATP) supplementation being touted as an enhancer of high intensity repetitive exercise performance. For a quick recap on the energy producing pathways of ribose seen.

The way OA enhances the formation of ATP is by providing the direct precursor to phosphoribosylpyrophosphate (PRPP) a key energy-supplying compound in the de-novo synthesis of purine and pyrimidine nucleotides (I know that's a real mouthful). The reserve of PRPP is poor because of the low capacity of the pentose phosphate pathway. Therefore the generation of ribose-5-phosphate (R-5-P) the immediate precursor to PRPP ribose supply can be enhanced with OA and as a result greater ATP regeneration.

2. The second pathway is by increasing the pool of Uridine Monophosphate (UMP), which requires ATP to convert to further downstream pyrimidine nucleotides (UTP & CTP). By increasing the levels of these nucleotides the draw on ATP reserves to synthesize them is decreased thereby enhancing the availability of ATP for other metabolic process such as energy and contractile producing pathways.

3. The final pathway is by means of elevation of intracellular glycogen stores. These elevated glycogen stores generated from a greater uptake of glucose lead to an enhanced capacity for ATP resynthesis from anaerobic glycolysis.

What this means is more energy for hard working muscles. Evidence also suggests OA can be used to synthesize carnosine (the ultimate buffering nutrient) by elevating its natural precursor “beta-alanine”. This is illustrated in the chart below:

More recent studies have shown OA supplementation enhances endurance performance and exercise capacity. OA also has been shown to augment muscle hypertrophy and to increase the contractile capacity of muscle.